%0 Journal Article %T Fluid assistance therapy reduces risks of hospital-acquired pulmonary fungal infection for acute exacerbation of chronic obstructive pulmonary disease patients %A Chen, Weisong %A Zhu, Dan %A Chen, Hui %A Luo, Jianfeng %J Journal of Emergency and Critical Care Medicine %D 2018 %B 2018 %9 %! Fluid assistance therapy reduces risks of hospital-acquired pulmonary fungal infection for acute exacerbation of chronic obstructive pulmonary disease patients %K %X Background: This study compares the effects of fluid assistance therapy on the probability of hospital-acquired pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in groups C and D of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Methods: We investigated AECOPD patients in GOLD groups C and D who were hospitalized in the pneumology department of our hospital from March 2013 to February 2016. The study was a cohort study. The patients were randomly divided into two groups using random number list: one that received fluid assistance therapy and one that did not. Binary classification logistic regression analysis was carried out using factors such as fluid assistance therapy, glucocorticoid use, long-term smoking history, use of long-term broad-spectrum anti-infection drugs and hypoproteinemia. Results: The pulmonary fungal infection probability of the fluid assistance therapy group was significantly lower (P=0.022). Except for long-term smoking history and fluid assistance therapy, all factors examined in the logistic regression analysis were risk factors for pulmonary fungal infection (P values: 0.008, OR 4.992, 95% CI: 1.516–16.438; 0.001, OR 7.693, 95% CI: 2.221–26.650, and 0.003, OR 6.393, 95% CI: 1.901–21.498, respectively). Fluid assistance therapy was a protective factor (P=0.001, OR 0.035, 95% CI: 0.005–0.246). Conclusions: Fluid assistance therapy can reduce hospital-acquired pulmonary fungal infection in group C and group D AECOPD patients. This therapy may be a protective factor and help to prevent pulmonary fungal infection. %U https://jeccm.amegroups.org/article/view/4354 %V 2 %P %@ 2521-3563