Infections in elderly intensive care unit patients
Review Article

Infections in elderly intensive care unit patients

Garyphallia Poulakou1, Styliani Lagou1, Stamatis Papadatos1, Ioannis Anagnostopoulos1, Margarita Papatheodoridi1, George Dimopoulos2

13rd Department of Medicine, Athens National and Kapodistrian University, School of Medicine, Sotiria General Hospital of Athens, Athens, Greece; 2Department of Critical Care, National and Kapodistrian University of Athens, School of Medicine, Attikon University General Hospital, Athens, Greece

Contributions: (I) Conception and design: G Poulakou, G Dimopoulos; (II) Administrative support: None; (III) Provision of study material: All authors; (VI) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of the manuscript: All authors.

Correspondence to: Garyphallia Poulakou, MD, PhD. 3rd Department of Medicine, Athens National and Kapodistrian University, School of Medicine, Sotiria General Hospital of Athens, 152 Mesogion St, Postal Code 11527, Athens, Greece. Email: gpoulakou@gmail.com.

Abstract: The elderly population is increasing in the developed world, therefore elderlies account for a considerable proportion of intensive care unit (ICU) admissions. A precise threshold for “elderly” is a matter of debate. The process of ageing is associated with physiological and functional alterations of the human body and organs that render elderly people vulnerable to infections. As a result of dysfunction of specific parts of immune response called immunosenescence, elderly patients may be threatened by severe infections. Chronic low-grade inflammation, termed inflammaging, is another contributor. In addition to these, comorbidities associated with increasing age, such as diabetes mellitus and immunosuppressive conditions pose an additive risk for infections and in some studies they were associated with increased mortality. Epidemiology of ICU infections may differ in elderlies, compared to other adults. Infections tend to be less microbiologically confirmed and site of infection may be obscure on presentation. The identified pathogens are frequently Gram-negative and particularly Enterobacteriaceae exhibiting a multidrug-resistant (MDR) phenotype. Multiple antibiotic prescriptions in this age-group, specific comorbidities (such as bronchiectasis or chronic obstructive pulmonary disease), residence in long term care facilities and frequent hospitalisations, are among others recognized risk factors for MDR infections. Data from two large European databases show that intra-abdominal infections are predominant among ICU infections in the elderly and Candida spp infections rank second, after Enterobacteriaceae. Age may pose important implications in treatment decisions. Organ derangements, physiological changes caused by increasing age and multiple concomitant medications call clinicians for vigilance about adverse events and toxicity. Despite all the above, elderlies in the ICU did not exhibit worse outcomes compared to younger counterparts in a straightforward manner. Studies however are heterogenous and most of them are single centers. As age is a continuous process, only analysis performed in subgroups of 65–74 (young-old elderlies), 75–84 (old elderlies) and >85 (old-old or oldest old elderlies) provides a better depiction of ICU outcomes. Most studies have shown a worse ICU outcome for the group of oldest-old elderlies, compared with young adults and elderlies in the range of 65 to 84 years of age. These data indicate that age per se may not represent a barrier in decisions concerning ICU admission and triage has to be done on an individual basis. However, epidemiological particularities of this age group should be taken into account in the selection of early and appropriate antimicrobial treatment, which will optimize patients’ outcomes.

Keywords: Ageing; elderly patients; immunosenescence; intra-abdominal infections; fungal infections; intensive care unit admission (ICU admission)


Received: 02 December 2018; Accepted: 26 February 2019; Published: 17 September 2019.

doi: 10.21037/jeccm.2019.09.01


Introduction

Elderly population is increasing in the developed world, both in terms of absolute numbers and proportion of the entire population. In the UK, from 1982 to 2002, life expectancy at the age of 80 increased from 5.8 years to 7.2 years in men and from 7.5 to 8.7 years in women. Trends are similar in other countries where elderlies represent more than 10% of ICU admissions (1-3). Infection, either as a cause of admission to intensive care units (ICU) or as complication during the ICU stay, represents a major health-care issue. It is estimated that elderly adults account for 60% of all ICU days, indicating a prolonged and frequently complicated length of stay (LOS) in an environment with increased rates of nosocomial infections owing to the severity of illness, multiplicity of invasive procedures and complexity of antibiotic and non-antibiotic treatments (3-6). Large epidemiological studies on outcomes of elderly adults after ICU admission are limited. Most data derive from small reports usually from single centers, describing a particular infection or syndrome, while few studies are available on ICU acquired infections (7-14). The most frequent infections in the ICU are respiratory infections, followed by urinary tract (UTIs) and bloodstream infections (BSIs) including catheter related infections (CRIs) (15,16). The definition of elderly patient is a matter of debate. The adult of 65 years old is considered elderly due to insurance reasons. However, aging is a continuous and host-specific process, therefore the subgroups of 65–74 (young-old elderlies), 75–84 (old elderlies) and >85 (old-old or oldest old elderlies) have been used (4,17-30).


Immune function in elderlies

The reasons why elderly individuals are vulnerable to life-threatening sepsis are multifactorial, including the pathophysiology of aging, the age-related reduction of organ function as well as the comorbidities and the polypharmacy (Table 1, Figure 1) (31). The modern definition of modifications in the immune system related to growing age, is described as immunosenescence, a process including anatomical changes (skin/vaginal atrophy, prostate hypertrophy, incomplete bladder emptying, diminished mucous production etc.) and cellular modifications (decreased chemotaxis/phagocytosis by macrophages/monocytes and neutrophils, superoxide production, alterations in both the expression of cell surface receptors and the signal transduction (32-34). The stimulation of macrophages toll-like receptor results in decreased production of tissue necrosis factor-a (TNFa) and interleukin-6 (IL6), while diminished expression of major histocompatibility complex (MHC) II allows to a reduced capacity for antigen presentation, mainly concerning dendritic cells (33,34). Finally the absolute number of natural killer (NK) cells increase in order to counterbalance a shift to a modified phenotype, with reduced cytotoxic activity and cytokines production which diminish the activation of both DCs and adaptive system response (34,35). Beyond these, various stressors changes in gut microbiota (predominantly endogenous, such as cell debris-products of damaged cells/organelles) and cells senescence-associated secretory phenotype (SASP) (36-38) have been correlated with chronic low-grade inflammation, known as inflammaging (39). Recently, it was proposed that monocytes, after an epigenetic change, promoting metabolic shift towards anaerobic glycolysis, acquire a pro-inflammatory phenotype which also conveys a kind of memory to the innate immune system (trained immune system). This is speculated to be at the center of inflammaging (40).

Table 1
Table 1 Functional modifications in elderlies, associated with vulnerability to infections [adapted from (31)]
Full table
Figure 1 Components of ageing which promote vulnerability to infections.

Modifications in the adaptive immune system seem to be much more investigated. B cells number and diversity are depleted; while their functionality is also altered, due to mRNA instability, resulting in decreased class switching and antibodies production (41,42). T cells are generally divided into two great subpopulations; CD4+ T cells-regulator and memory cells- and CD8 T cells-memory and effector cells. Aging seems to result in a reduced production of their progenitor cells, naive T-cells, via a shift in the hematopoietic stem cell to myeloid lineage (43) in addition to the thymus involution (44). Furthermore, the increased turnover rate that has been reported for peripheral naive CD8+ T cells in elderly (CD4+ compartment is maintained) results in the accumulation of reverted and virtual memory cells, which are not truly naive, thus further compromising their population (45,46). In terms of terminally differentiated T-cells, especially CD8+, their proliferation is highly oligoclonal (47), something which is more evident with latent viral infections. Indeed CD8+ T-cells specific for Varicella Zoster virus (VZV) tend to decrease (increasing reactivation) while the opposite applies for Epstein-Barr virus (EBV) and Cytomegalovirus (CMV) (48). The latter was initially proposed to have deleterious effects but subsequent studies are controversial (49). Instead of that, T-cell receptor repertoire although decreasing with aging, still remains wide (50). The above-mentioned clones undergo various epigenetic changes and acquire either a senescent (low proliferation/maintained cytokines production) or an exhausted phenotype (low proliferation/cytokine production) (51). The sum of these changes in addition to the diminished survival and functionality of T-cells, caused by inflammaging (51), increase vulnerability to infections and limit vaccination effectiveness.


Risk factors, epidemiology and infections in elderly ICU population

Approximately 60% of patients with sepsis are >65 years old (30). The comorbidities in the elderly population have a major role for the development of ICU infections (52). A large study of 30,239 community-dwelling participants showed that incident sepsis in the ICU was associated with a baseline history of chronic lung disease (adjusted HR: 2.43; 95% CI: 2.05–2.86), peripheral artery disease (adjusted HR: 2.16; 95% CI: 1.58–2.95), chronic kidney disease (adjusted HR 1.99; 95% CI: 1.73–2.29), myocardial infarction (adjusted HR 1.79; 95% CI: 1.49–2.15), diabetes (adjusted HR 1.78; 95% CI: 1.53–2.07), stroke (adjusted HR 1.67; 95% CI: 1.34–2.07), deep vein thrombosis (adjusted HR 1.63; 95% CI: 1.29–2.06), coronary artery disease (adjusted HR: 1.61; 95% CI: 1.38–1.87), hypertension (adjusted HR 1.49; 95% CI: 1.29–1.74), atrial fibrillation (adjusted HR 1.48; 95% CI: 1.21–1.81) and dyslipidemia (adjusted HR: 1.16; 95% CI: 1.01–1.34). Risk of sepsis increased with the total number of chronic medical conditions (53). Immunosuppressive diseases (such as AIDS and cancer), immunosuppressive medications, diabetes, alcohol abuse, indwelling catheters or conditions involving altered skin integrity, predispose to ICU infections (54). A recent study from Australia, that examined 4,137 patients above 80 years admitted to the ICU for sepsis over a 15-year long period [2000–2015], demonstrated that the most prevalent comorbidity in these patients was chronic cardiovascular disease (9.5%), followed by chronic respiratory disease (7.3%) and diabetes mellitus type I (4.8%) (55).

When examining potential underlying mechanisms, longstanding diabetes mellitus may increase infection risk due to peripheral neuropathy, poor vasculature and delayed phagocytosis leading to decreased clearance of yeast and bacteria by neutrophils (56). Similar immune deficiencies contribute to infections in case of chronic kidney disease (57), whereas chronic liver failure causes impairment of complement factor formation and proliferation of cellular immunity. COPD patients may present impaired mucociliary clearance, alveolar macrophage dysfunction, and suppressed cough mechanism, thus increasing the risk for lower respiratory tract infections. Frailty is considered an indirect risk factor for elderly hospitalization and therefore in-hospital infections and ICU admission (58). Finally, it has also been recently shown that patients with septicaemia, especially of higher severity, seem to have a higher risk for developing dementia after hospitalization (59).

There are very few large-scale studies focused on ICU Acquired Infections in this population and the data are scarce and controversial. Most of them derive from single centers and target one type (4,7-17) of infection (18-32). The most frequent IAIs are respiratory infections, followed by UTIs and BSIs including (7-15) CRIs (4,16-29). The most important studies reporting on epidemiology and outcomes of elderly ICU patients are summarized in Table 2.

Table 2
Table 2 Major studies exploring outcomes of ICU-admitted elderly patients (4,7,10,12,13,18-20,24,25,60)
Full table

An analysis of data from an international, observational, point-prevalence study: Extended Prevalence of Infection in Intensive Care (EPIC II), stands out as one of the largest epidemiological studies in the field. The authors aimed to determine the effect of age on patterns of infection and on outcomes. The study encompassed 1,265 ICUs in 75 countries (66% mixed medical-surgical ICUs) and 13,796 adults of whom 7,087 (51.4%) had an infection. Among them, 1,713 (24.2%) were 65 to 74, 1,405 (19.8%) were 75 to 84, and 330 (4.7%) were aged 85 and older. Those aged 85 and older had proportionately more abdominal infections, fewer BSIs, more Gram-negative pathogens and higher mortality rates compared to younger counterparts (60). Quite striking in respect to the worldwide distribution of the prevalence study, surgical emergency predominated as admission cause across all age groups, however displaying a linear increase with age, ranging from 41% in young adults aged 18–44 years to 51% in adults aged ≥85 years (60). Maillet et al. studied a subgroup of overaged ICU population (>80 yrs old) and found that of the 343 IAI, 19% occurred in the elderly group (43% was respiratory infections, 24% UTIs, 21% BSIs, 4.5% CRIs and 0.5% others). Elderly and younger patients with ICU acquired infections were predominantly infected by Gram-negative organisms (56.6%) and had significantly prolonged ICU stay but ICU mortality rates were significantly higher for elderly compared with younger patients (38.6% vs. 25.0% respectively, P<0.001) (61). Sousa et al. in a study of 308 elderly, described respiratory tract infections in 49.7%, UTIs in 33.8%, BSIs in 21.1% and surgical site infections in 4.9%. In three age sub-groups: 60 to 69 years, 70 to 79 years and over 80 years, the mortality rate was 46.8%, 49.5% and 64.9% respectively and according to the Kaplan-Meier survival curve, hospital mortality in the elderly who developed ICU infection did not have large variations among age groups (62). In line with this, Hifumi et al. over a 7-year study period, retrospectively investigated patients with CAP who required mechanical ventilation (3 age groups: 65–74, 75–84, and ≥85 years) and concluded that age itself was not significantly associated with weaning from mechanical ventilation (P=0.59), in-hospital mortality (P=0.90), ventilator-free days (P=0.83) or ICU days (P=0.12) among the 3 age groups (63).

Critically ill elderly patients are particularly vulnerable to ICU-BSI, which is associated with prolonged LOS, resulting in excess costs and high mortality. In most cases ICU-BSIs are secondary to UTI, lung, soft tissue or intra-abdominal infections. Even if no causative was identified in over the half cases of sepsis, Gram-negative bacteria were 1.31 times more likely to be the cause of sepsis among patients 65 years or older, with respiratory and genitourinary sources being the most common causes (15). Staphylococcus aureus is the most common isolated in all age groups, but in the elderly group is more often drug-resistant (64). Apart from the methicillin-resistant Staphylococcus aureus (MRSA), there is data supporting that other Gram-negative and Gram-positive multi-drug resistant (MDR) are increasingly isolated in the elderly, including vancomycin-resistant enterococci (VRE) and extended spectrum b-lactamase (ESBL) Klebsiella spp strains (65,66). Moreover, elderly population is at higher risk of infections due to Pseudomonas aeruginosa because of frequent antimicrobial and/or steroid use (recurrent infections, COPD exacerbations, autoimmune diseases), structural lung diseases (bronchiectasis, in respiratory infections) and the great number of residents in nursing homes and assisted living facilities (67).

Enterobacteriaceae are the most frequent family of microorganisms isolated in UTIs according to recent epidemiological data from EARSS-NET, representing 45.3% of all isolated microorganisms with Candida spp ranking second. Although E. coli is the predominant in all ages, other Gram-negative bacteria, such as Proteus spp, Klebsiella spp, and Pseudomonas spp. are more frequent isolated in older population (68,69).


Elderly with fungal infections in the ICU

The incidence of candideamia in elderly critically ill patients has no differences compared to younger patients (60). However, in the elderly population there are differences regarding the outcome. In a post hoc analysis of a non-comparative, prospective, multicentre, phase IIIb study the global success rate and the incidence/profile of adverse events with IV anidulafungin treatment against confirmed candideamia were similar in elderly and non-elderly patients at EOT in mITT but the 28-days mortality was higher in elderlies because this population during the entry in the study had more comorbidities and higher APACHE II and SOFA scores (70). In patients with intraabdominal candidiasis, differences have been noted between elderlies and non-elderlies regarding the incidence and outcomes. In a post-hoc analysis of a retrospective multinational cohort study, 482 patients were included, 124 (25.7%) of them being elderly and 358 (74.3%) non-elderly. Mortality was significantly higher in the elderly group, while factors independently predicting mortality in elderly patients were end-stage renal disease and inadequate abdominal source control (71). Data regarding the epidemiology and diagnosis of invasive aspergillosis (IA) in the critically ill population are limited, with data regarding elderly patients (the critically ill populatioA prospective, international, multicenter observational study (AspICU study) including adult ICU patients, with a culture and/or direct examination and/or histopathological sample positive for Aspergillus spp. at any site reported that elderly and non-elderly ICU patients with IA differed in a number of characteristics, including comorbidities, clinical features of the disease, mycology testing, and radiological findings. No difference regarding mortality was found. Elderly patients had less diagnostic radiological findings and when these findings were present they were detected late in the disease course. All patients who were diagnosed with proven IA died (72).


Therapeutic considerations in elderly ICU patients

There are certain particularities concerning the treatment of critically ill elderly (Figure 2). Septic patients older than 65 years old are twice as likely to suffer from at least one chronic comorbidities and three times more likely to have a coincident diagnosis of coronary artery disease or congestive heart failure (15). Renal and hepatic impairment may also be present in the elderly and therefore potentially nephrotoxicity or hepatotoxicity of the medication used should be carefully considered.

Figure 2 Main physiological changes and organ derangements that affect the pharmacokinetics and pharmacodynamics in the elderly.

Renal aging is a complex process which plays an important role on pharmacokinetics. Nephron loss, glomerulosclerosis and tubulointerstitial fibrosis predispose to acute kidney injury in the elderly population especially when individuals are treated with nephrotoxic agents (73). Deterioration of renal function leads to accumulation of active metabolites of certain drugs which consequently results in vulnerability to a certain drug effect (74) and increased adverse drug interactions, especially as far as hydrophilic molecules is concerned. It is well documented that sarcopenia is an independent risk factor for mortality in elderly ICU patients (75). In such patients, measured serum creatinine may be falsely low due to the reduction in muscle mass (76) and this fact could probably lead to an overestimation of renal function. Even if age-adjusted equations are used for GFR estimation, the latter should be carefully interpreted (77), as they may represent frailty (78), malnutrition, cachexia or even inflammation (79). Furthermore, the high adipose tissue content in the elderly individuals and the consequent sarcopenia plays an important role in lipophilic and hydrophilic drugs metabolism and more specifically to certain classes of antibiotics (80).

Pseudocapillarisation of the liver sinusoidal endothelial cells, dysregulation of Kupffer cell activation and age-related changes in hepatic metabolism may explain the pharmacokinetics and pharmacodynamics of hepatic metabolism of the drugs concerning the elderly (81). Hepatic parenchymal mass and blood flow notably decrease in the elderly while changes in liver enzymes are present as well (82). All these changes do affect the administration of certain medications as it is suggested that the dosage of high clearance drugs should be reduced by approximately 40% in the elderly while the dosage of low clearance drugs should be reduced by approximately 30% (83). Finally, the reduced gastric acidity and the impaired intestinal motility may retard the dissolution and absorption rate of the enterically administered drugs or supplements (84). Older adults admitted to ICU are pretreated with an average of twelve different medications (85). As if this were not enough, prescription and nonprescription medications, namely over-the-counter medications, herbal and dietary supplements are now widely used by the elderly (86) and this could lead to unpredictable drug-to drug interactions (87). In a prospective study Doan et al. demonstrated that the probability of a drug-to-drug interaction increased with the number of medications and reached 100% when a patient was treated with 20 or more medications (88). Given the fact that more than 70% of ICU patients receive multiple antibiotics, usually empirically (89), those interactions seem more probable especially when referring to the elderly (90). Despite all the reservations mentioned above, clinicians should not withhold lifesaving treatment options for the sake of advanced age alone (91).


Conclusions

The elderly population is increasing in the developed world, therefore elderlies account for a considerable proportion of ICU admissions. As a definition “elderly” is a matter of debate, subgroups of 65–74 (young-old elderlies), 75–84 (old elderlies) and >85 (old-old or oldest old elderlies) have been used to explore ICU outcomes in this population in line with the continuous character of ageing process. Vulnerability of elderly people in infections and severe infections requiring advanced support has been thoroughly elucidated by physiological and functional alterations of the human body and organs, immunosenescence and inflammaging. Comorbidities associated with increasing age, such as diabetes mellitus, renal insufficiency and immunosuppressive conditions pose an additive risk for infections. Epidemiological differences of ICU infections in elderlies, compared to other adults include obscure presentation with predilection for intraabdominal foci, lower rates of microbiological confirmation and implication of MDR pathogens. MDR Enterobacteriaceae are very common, owing to multiple recognized risk factors for MDR infections in this age group, such as multiple antibiotic prescriptions, specific comorbidities (such as bronchiectasis or COPD), residence in long-term-care facilities and frequent hospitalisations, among others. Data from a large European database showed that Candida spp infections rank second, after Enterobacteriaceae among elderlies with ICU infections. Organ derangements and multiple concomitant medications may pose important implications in treatment decisions, while calling for vigilance for adverse events and toxicity. Despite all the above, and the heterogeneity of most studies, elderlies did not have disappointing ICU outcomes. In particular, most studies have shown a worse ICU outcome for the group of oldest-old elderlies, compared with young adults and elderlies in the range of 65 to 84 years of age. These data indicate that age per se may not represent a barrier in decisions concerning ICU admission. However, due to the epidemiological particularities of this age group rigorous identification of the site of infection and pathogen should be sought, enabling selection of appropriate antimicrobial treatment and overall clinical management, which ultimately will optimize patients’ outcomes.


Acknowledgments

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.


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doi: 10.21037/jeccm.2019.09.01
Cite this article as: Poulakou G, Lagou S, Papadatos S, Anagnostopoulos I, Papatheodoridi M, Dimopoulos G. Infections in elderly intensive care unit patients. J Emerg Crit Care Med 2019;3:44.